Abstract

Paraquat (PQ) is a highly lethal bipyridyl herbicide. Its toxicity is driven by the generation of superoxide radicals, which lead to severe cellular damage. The ingested dose remains the factor with the greatest impact on mortality, and additional prognostic determinants include age, route of exposure, intentionality, and delays in initiating treatment. Although several interventions have been explored, including gastrointestinal decontamination, immunomodulation, and antioxidant therapy, extracorporeal support techniques continue to accumulate evidence for their use even when initiated late. We describe a successful case of delayed extracorporeal renal support therapy after ingestion of a lethal dose of PQ.